Reinventing the fight against bacteria, one phage at a time.

Antibiotic resistance: the crazy project of the Hospices Civils de Lyon against superbugs By  Camille Dubois  Health Journalist Written on 10/14/2025 Antibiotic resistance is now reaching proportions unimaginable even twenty years ago. Every year, doctors see the emergence of infections that they once struggled to treat due to a lack of effective drugs. Faced with this impasse, researchers are exploring other avenues. Among them, an old method is making a comeback: phage therapy. The idea seems simple, almost elegant: using viruses that attack only bacteria. In Lyon, a team recently published encouraging results, suggesting a credible alternative to conventional treatments. Summary An out-of-control phenomenon Breathless treatments A fragile but real hope An out-of-control phenomenon The figures are stark. According to the World Health Organization, more than 23 million infections have been recorded in 104 countries. And the findings are stark: one in six bacterial infections ...

PARADIGM – Personalised phAge therapy against gRam-negAtive multiDrug resIstant orGanisMs The PARADIGM project (project ANR-24-PEBI-0005) is part of the France 2030 plan and was selected by the French National Research Agency (ANR) via its Priority Research Programs and Equipment initiative on Biotherapies – PEPR Biothérapies. The project is led by Paris Public Hospital Network (Assistance Publique des Hôpitaux de Paris, AP-HP), in partnership with the Biological Resource Center of Institut Pasteur ( CRBIP ) and the French Alternative Energies and Atomic Energy Commission (Commissariat à l’énergie atomique et aux énergies alternatives, CEA). Given the health emergency represented by antibiotic resistance, the aim of the PARADIGM project is to support personalized phage therapy development in France against, in principle, two priority multidrug-resistant pathogens:  Escherichia coli  and  Klebsiella pneumoniae . Bacteriophages, or phages, are viruses capable of infecting a...

Illinois-led Initiative Will Build Precision Phage Platform for Promoting Health Electron micrographs of bacterial viruses, also known as phages. Hatoum-Aslan lab, University of Illinois University of Illinois Urbana-Champaign scientists, including   bioengineering   professor   Sergei Maslov   and   microbiology  professor  Asma Hatoum-Aslan , will partner with investigators from several industrial and academic institutions on a five-year, up to $28M initiative funded by the Advanced Research Projects Agency for Health and overseen by Program Manager Andrew Brack, PhD. The project, “Microbe/phage Investigation for Generalized Health TherapY (MIGHTY),” aims to harness the natural predators of bacteria – known as phages – as precision tools to shape the human microbiome and promote health. “We are very excited to be hosting this project at the [Carl R. Woese Institute for Genomic Biology],” said IGB Director Gene Robinson. “The new ARPA-H agency aims to...

Isolation, Engineering, and Ecology of Temperate Phages in the Human Gut The human gut contains a large and dynamic microbial ecosystem that includes numerous bacteriophages. Temperate phages capable of lysogeny play an important role in shaping bacterial diversity, facilitating gene exchange, and maintaining ecological stability. Recent metagenomic advances have revealed immense viral diversity within the gut microbiome; however, the functional behavior and induction dynamics of prophages remain poorly understood. About 90% of gut bacteria have prophages, yet the triggers and conditions that cause the transition from the lysogenic to the lytic cycles are not fully characterized. It is necessary to understand these dynamics to elucidate the phage-driven modification of host microbial populations and their potential roles in human health and disease. This study aimed to identify inducible prophages in diverse human gut bacterial isolates and to determine how environmental stimuli, polyl...