Reinventing the fight against bacteria, one phage at a time.

Interview with Bassim Karaman on phage therapy Bassim Karaman recounts his medical journey after undergoing knee replacement surgery and developing an infection. Karaman was treated with phages at the Geneva University Hospitals, which most likely saved him from having to have his leg amputated. More information at https://forumphage.ch 0:00 What happened after the knee replacement 3:54 Living with an infection and no joint in his left knee 4:51 Dead end 5:46 The hope of phage therapy 6:24 Phage treatment 7:10 Effects of treatment 8:02 After phage treatment: one in two germs reappears 9:15 Three years later 10:35 But osteoarthritis remains 11:18 Is there a need for phage therapy?

Interview on phage therapy with Dr. Truong-Thanh Pham, HUG (French with subtitles) Infectious disease specialist Truong-Thanh Pham, from the Geneva University Hospitals (HUG), tells us about the consequences of antibiotic resistance for his patients, phage therapy, and how he most likely prevented a patient (Bassim Karaman) from having to have his leg amputated using phages. Pham also discusses the current obstacles to phage therapy and ways to improve the situation. More information at https://phagenforum.ch/fr/ 0:00 What types of antibiotic resistance do you encounter in the clinic? 1:20 What does this mean for your patients with infected implants? 2:06 What is the impact on patients' quality of life? 2:46 Can you talk about Mr. Karaman, whom you treated with phages for an infected knee prosthesis? 3:37 What would have been the consequences for Mr. Karaman if no treatment had been effective? 4:18 How did the phage treatment go? 5:12 In your opinion, what are the str...

Viruses, a hope against antibiotic resistance Antibiotic-resistant germs are posing increasing challenges to medicine. There is a great need for complementary treatments. One of these could be phage therapy, as a new film shows. Image:  Andres Jordi Phages are viruses that only attack and destroy bacteria. This can be used as therapy if a virus adapted to the pathogenic bacteria is found. In Switzerland, phages can currently only be used in emergencies. But how exactly does phage therapy work? How and where is it already used? And what are its limitations? The film "Phage Therapy – Medicine Goes Viral" by science journalist Thomas Häusler, produced for the Forum for Genetic Research, answers these and many other questions. Available with english subtitles ! Copyright belongs to, taken from :  https://geneticresearch.scnat.ch/fr/uuid/i/6e5fc24b-fe38-5822-8d4d-28af9bd5caa1-Les_virus_un_espoir_contre_la_r%C3%A9sistance_aux_antibiotiques

Proteolytic Inactivation Follows Genomic Hypomethylation in Pseudomonas Ai generated In the ongoing microbial arms race between bacteria and bacteriophages, restriction-modification (R-M) systems stand out as some of the most ancient and effective bacterial defense strategies. These systems function by distinguishing self from non-self DNA, enabling bacteria to cleave invading viral genomes while sparing their own. However, this form of molecular immunity is fraught with inherent risk; given the sheer number of potential restriction sites littered across a bacterial genome, the possibility of autoimmunity — the accidental degradation of self-DNA — remains a persistent threat with potentially lethal consequences. A recent breakthrough study from Shmidov et al. sheds new light on how  Pseudomonas aeruginosa , a clinically significant opportunistic pathogen, modulates its restriction endonucleases to circumvent self-destruction, with fascinating implications for bacterial physiology a...

Armata Pharmaceuticals Announces Structural Biology Publication in the Journal of Molecular Biology Describes the structure of phage Pa223, which is included in Armata's multi-phage anti- Pseudomonas  clinical candidate, AP-PA02 LOS ANGELES ,  Sept. 8, 2025  /PRNewswire/ -- Armata Pharmaceuticals, Inc. (NYSE American: ARMP) ("Armata" or the "Company"), a clinical-stage biotechnology company focused on the development of high-purity, pathogen-specific bacteriophage therapeutics for the treatment of antibiotic-resistant and difficult-to-treat bacterial infections, today announced a paper in the  Journal of Molecular Biology (JMB) . The publication, titled, "High-resolution Cryo-EM Analysis of the Therapeutic  Pseudomonas  Phage Pa223," describes the structure of phage Pa223, which is included in Armata's five-phage clinical cocktail, AP-PA02. Armata is developing AP-PA02 as a potential treatment for chronic respiratory infections in people with cysti...

Development of Phage Therapy for Curing Acne Vulgaris Using Phage PA6 Taken from :  https://www.emjreviews.com/wp-content/uploads/2025/09/Development-of-Phage-Therapy-Web-455x273.png Authors: Suraj Pal  ,  1   Medha Singh  ,  1   *   Manoj Singh  1 1. Department of Bio-Sciences and Technology, Maharishi Markandeshwar Engineering Campus, Maharishi Markandeshwar (Deemed to be University), Haryana, India *Correspondence to  manoj.singh@mmumullana.org Disclosure: The authors have declared no conflicts of interest. Received: 20.03.25 Accepted: 01.07.25 Citation: EMJ .  2025 ; 10 [ 3 ]: 63 - 65 .   https://doi.org/10.33590/emj/OJOG7100 . Keywords: Acne vulgaris,  Cutibacterium acnes,  phage PA6. Each article is made available under the terms of the   Creative Commons Attribution-Non Commercial 4.0 License . INTRODUCTION Acne vulgaris, commonly known as acne, is a skin disease caused by the blockage of hair follicles, h...